DDIs can be roughly classified into two main types: pharmacokinetic (PK) and pharmacodynamic (PD). When taking two or more drugs at the same time or in succession, the activity of one drug may be alerted significantly due to the presence of other drugs, which is described as DDI. ĭrug–drug interaction (DDI) is one of the most important concerns in clinical rational administration and post-marketing pharmacovigilance ( 1, 2). DDInter is freely available, without registration, at. We hope that DDInter will prove useful in improving clinical decision-making and patient safety. It can also be used for informatics-based DDI investigation and evaluation of other prediction frameworks. In addition to basic query and browsing, the prescription checking function is developed to facilitate clinicians to decide whether drugs combinations can be used safely.
The drug entities and interaction entities are efficiently cross-linked. For DDI associations, abundant and professional annotations are provided, including severity, mechanism description, strategies for managing potential side effects, alternative medications, etc. Each drug is annotated with basic chemical and pharmacological information and its interaction network. Currently, DDInter contains about 0.24M DDI associations connecting 1833 approved drugs (1972 entities). To facilitate the clinicians to screen for dangerous drug combinations and improve health systems, we present DDInter, a curated DDI database with comprehensive data, practical medication guidance, intuitive function interface, and powerful visualization to the scientific community. Despite the continuous information accumulation of clinically significant DDIs, there are few open-access knowledge systems dedicated to the curation of DDI associations. Drug-drug interaction (DDI) can trigger many adverse effects in patients and has emerged as a threat to medicine and public health.
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